BIOMARKERS AND BMI

Title of Study: To screen platelet reactivity in the general Irish Population.

Researchers: Ms. Laura Twomey, Dr. Ronan Murphy.

Location

Science Gallery, Trinity College, Dublin.

Introduction

The purpose of this project is to profile platelet reactivity in a cohort of the Irish population. Platelets are tiny fragments of larger cells which circulate within the blood stream. Their main function is to aid in primary hemostasis - blood clotting. They complete this by sticking to an injured vessel wall and then sticking to each other to form a small clot. Platelet activity can vary amongst individuals of varying health status/fitness/age and is increasingly being noted as a marker of vascular health.

Exclusion from participation: You cannot participate in this study if you are:

  • Under the age of 18
  • Know you are, or think you might be, infected with Hepatitis B or C
  • Know you are, or think you might be, infected with HIV (the AIDS virus) have, or have had a sexual partner who is infected with hepatitis or HIV.
  • Are, or may be pregnant.

Procedures

In order to obtain results I understand that the following procedures need to take place:

  • I am required to complete a general questionnaire for FAT and a specific questionnaire for the platelet test.
  • A single, small (4.5ml) blood sample will be taken for this test.. This will take about five minutes.
  • This blood sample will be processed on the cone and plate analyser to determine platelet function and the blood counter to determine platelet count.

Why is blood sampling required? Platelet activity can only be measured in blood samples. An instrument called a cone and plate analyser will help to measure your platelet activity.

Benefits

This test will be extremely informative and will provide you with a better understanding of how blood cells work in the body. You will be provided with your own full platelet function profile screen readout which includes platelet number, platelet activity - adhesion and aggregation.

Risks

There are no major risks involved. Blood will be taken by a qualified phlebotomist. You may feel a slight discomfort when the sample is drawn, a very small needle size is used to reduce this. A tiny bruise could develop where the sample took place. There is a small risk of fainting, participant can choose to sit or lie down for the test.

Confidentiality

Your identity will remain confidential. Your name will not be published and will not be disclosed to anyone outside the study group. Data will be stored in password protected files at Science Gallery Trinity College.

The research may be used for a PhD thesis, published in scientific journals and / or presented and discussed at scientific meetings, without revealing any of my personal details.

Compensation

This study is covered by standard institutional indemnity insurance. Nothing in this document restricts or curtails your rights.

Voluntary Participation

This research is voluntary and you may decide to withdraw at any stage.

Stopping the study

I understand that the investigators may withdraw my participation in the study at any time without my consent.

Permission

This study has ethical approval from TCD and DCU ethics.

Further information: Please contact Dr. Ronan Murphy or Ms. Laura Twomey who can be contacted at 017008824 or laura.twomey2@mail.dcu.ie for any further information you require.

Biomarkers and BMI

How ‘sticky’ are your platelets? How does this connect with your BMI, fitness and health? This blood test looks at your platelet reactivity and reveals what your platelets look like in real time.